Journal of Molecular Medicine

, Volume 92, Issue 9, pp 913–924

Molecular and cellular basis of scleroderma

Authors

  • Beate Eckes
    • Department of DermatologyUniversity of Cologne
  • Pia Moinzadeh
    • Department of DermatologyUniversity of Cologne
  • Gerhard Sengle
    • Center for BiochemistryUniversity of Cologne
    • Center for Molecular Medicine Cologne (CMMC)University of Cologne
  • Nico Hunzelmann
    • Department of DermatologyUniversity of Cologne
    • Department of DermatologyUniversity of Cologne
    • Center for Molecular Medicine Cologne (CMMC)University of Cologne
    • Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)University of Cologne
Review

DOI: 10.1007/s00109-014-1190-x

Cite this article as:
Eckes, B., Moinzadeh, P., Sengle, G. et al. J Mol Med (2014) 92: 913. doi:10.1007/s00109-014-1190-x

Abstract

Systemic sclerosis (scleroderma) is a chronic inflammatory disease that leads to fibrosis of the skin and involved internal organs. No efficient therapy is currently available. This review summarizes recent progress made in basic as well as clinical science and concludes with a concept that therapy targeting fibrosis in scleroderma needs to take into account the global microenvironment in the skin with its diverse cellular players interacting with a complex extracellular matrix environment and matrix-associated growth factors.

Keywords

Systemic sclerosis Scleroderma Extracellular microenvironment Pathophysiology Signaling

Copyright information

© Springer-Verlag Berlin Heidelberg 2014