Journal of Molecular Medicine

, Volume 92, Issue 7, pp 723–733

Growth factor transduction pathways: paradigm of anti-neoplastic targeted therapy


DOI: 10.1007/s00109-014-1177-7

Cite this article as:
Carlomagno, F. & Chiariello, M. J Mol Med (2014) 92: 723. doi:10.1007/s00109-014-1177-7


Molecularly targeted cancer treatment has become an achievable goal thanks to systematic analysis of cancer genome as well as development of highly selective tumor targeted drugs. In many human cancers, deregulation of the RTK/RAS/MAPK pathway is the driving force of the disease. Indeed, cancer cells become addicted to such signaling, rendering them susceptible to drugs that can intercept growth factor signaling cascade at different levels. Discovery of mutations or aberrant expression of components of this cascade in radio- and chemotherapy refractory human melanoma acted as an enormous stimulus for scientist to try to identify and clinically test new therapeutic approaches blocking the RTK/RAS/MAPK cascade. These efforts not only resulted in the identification of new drugs for melanoma treatment but also in a better understanding of molecular basis of primary and secondary resistance to targeted therapies.


MAPKTargeted therapyKinase inhibitorMelanoma

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Dipartimento di Medicina Molecolare e Biotecnologie MedicheUniversità degli Studi di Napoli Federico IINaplesItaly
  2. 2.Core Research Laboratory and Istituto di Fisiologia ClinicaIstituto Toscano Tumori and Consiglio Nazionale delle RicercheSienaItaly