, Volume 91, Issue 4, p 409
Date: 21 Mar 2013

Advances in cancer biology and therapy

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This issue of the Journal of Molecular Medicine contains three outstanding review articles that summarize recent advances in cancer metastasis and anti-angiogenic therapy by leaders in the field. Interactions between cancer cells and stromal cells play critical roles in the metastatic process, which in turn is the major cause of cancer mortality. Among the stromal cell types that are discussed in these review articles are cancer-associated fibroblasts, inflammatory cells, and endothelial cells.

Smith and Kang review the rapidly growing body of data regarding the mechanisms by which many different inflammatory cell types, including macrophages, myeloid-derived suppressor cells, neutrophils, regulatory T cells, and suppressive dendritic cells, are recruited to primary tumors and promote metastasis [1]. In addition, factors secreted by primary tumors also recruit bone marrow-derived cells to future sites of metastasis in the lungs and other organs, as part of the process known as pre-metas ...