Journal of Molecular Medicine

, Volume 90, Issue 9, pp 1059–1067

Genetic variants implicated in telomere length associated with left ventricular function in patients with hypertension and cardiac organ damage

  • Matthias Huber
  • Andras Treszl
  • Markus Wehland
  • Ingke Winther
  • Irina Zergibel
  • Rona Reibis
  • Juliane Bolbrinker
  • Monika Stoll
  • Gilbert Schönfelder
  • Karl Wegscheider
  • Heinz Völler
  • Reinhold Kreutz
Original Article

DOI: 10.1007/s00109-012-0874-3

Cite this article as:
Huber, M., Treszl, A., Wehland, M. et al. J Mol Med (2012) 90: 1059. doi:10.1007/s00109-012-0874-3

Abstract

Telomere length has emerged as a biological correlate for ageing, which in turn is a risk factor for the manifestation of cardiovascular diseases. This study investigated the relation between leucocyte telomere length (LTL) and its genetic background to cardiac structure and function in patients with arterial hypertension. We analysed a cohort of 1,106 treated hypertensive patients (83.3% males; mean age, 57.9 ± 9.8 years) with an ejection fraction (EF) over 40% and documented cardiovascular disease or target organ damage. LTL and genotypes of single nucleotide polymorphisms (SNPs), previously implicated in LTL, were determined by real-time PCR. The mean left ventricular mass index (LVMI) and EF were 51.8 ± 21.0 g/H2.7 and 61.1 ± 9.6%, respectively. In multivariate adjusted analysis, a 1.5-fold LTL was positively related with a 2.2% increase of LVMI (CI = 0.1% to 4.2%, p = 0.044) and an absolute increase in EF of 0.6% (CI = 0.1% to 1.1%, p = 0.028). One SNP near TERC (rs16847897) showed a significant absolute difference in EF dependent on allele status (rs16847897, G allele 2.7%; CI = 0.7% to 4.6%; praw = 0.008, pmt = 0.048, after adjustment for multiple testing). This applied also for two SNPs in BICD1 (rs2630578, C allele −1.8%; CI = −2.8% to −0.7%; praw = 0.002, pmt = 0.018; rs1151026, G allele −1.9%, CI = −3.0% to −0.8%; praw < 0.001, pmt = 0.002) with the extension that a frequent haplotype in BICD1 showed an absolute −1.8% (CI = −3.0% to −0.7%; praw = 0.002, pmt = 0.008) lower EF compared with those lacking this haplotype. Our results point to a role of genetic variants recently implicated in LTL for left ventricular function in hypertensive patients.

Keywords

AgeingCardiac outputEchocardiographyGeneticsHypertensionClinical researchHeart

Supplementary material

109_2012_874_MOESM1_ESM.doc (1.2 mb)
ESM 1(DOC 1197 kb)

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Matthias Huber
    • 1
  • Andras Treszl
    • 2
  • Markus Wehland
    • 1
  • Ingke Winther
    • 1
  • Irina Zergibel
    • 1
  • Rona Reibis
    • 1
    • 3
  • Juliane Bolbrinker
    • 1
  • Monika Stoll
    • 4
  • Gilbert Schönfelder
    • 1
  • Karl Wegscheider
    • 2
  • Heinz Völler
    • 1
    • 3
  • Reinhold Kreutz
    • 1
  1. 1.Institute of Clinical Pharmacology and Toxicology, CharitéCentrum für TherapieforschungCharité–Universitätsmedizin BerlinBerlinGermany
  2. 2.Department of Medical Biometry and EpidemiologyUniversity Medical Center Hamburg-EppendorfHamburgGermany
  3. 3.Klinik am SeeRehabilitation Center for Cardiovascular DiseasesRüdersdorfGermany
  4. 4.Leibniz-Institute for Arteriosclerosis ResearchUniversity of MünsterMünsterGermany