Review

Journal of Molecular Medicine

, Volume 90, Issue 8, pp 865-875

First online:

Circulating microRNAs: novel biomarkers for cardiovascular diseases

  • Jiahong XuAffiliated withDepartment of Cardiology, Tongji Hospital, Tongji University School of MedicineKey Laboratory of Arrhythmias, Ministry of Education, China (Shanghai East Hospital, Tongji University School of Medicine)
  • , Jiangmin ZhaoAffiliated withDepartment of Radiology, Shanghai Third People’s Hospital, Shanghai Jiaotong University School of Medicine
  • , Graham EvanAffiliated withCardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Medical School
  • , Chunyang XiaoAffiliated withCardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Medical School
  • , Yan ChengAffiliated withKey Laboratory of Arrhythmias, Ministry of Education, China (Shanghai East Hospital, Tongji University School of Medicine)Department of Psychiatry, Tongji Hospital, Tongji University School of Medicine Email author 
  • , Junjie XiaoAffiliated withKey Laboratory of Arrhythmias, Ministry of Education, China (Shanghai East Hospital, Tongji University School of Medicine)Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Medical School Email author 

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Abstract

MicroRNAs (miRNAs) are a novel class of small, non-coding, single-stranded RNAs that negatively regulate gene expression via translational inhibition or mRNA degradation followed by protein synthesis repression. Many miRNAs are expressed in a tissue- and/or cell-specific manner and their expression patterns are reflective of underlying patho-physiologic processes. miRNAs can be detected in serum or in plasma in a remarkably stable form, making them attractive biomarkers for human diseases. This review describes the progress of identifying circulating miRNAs as novel biomarkers for diverse cardiovascular diseases, including acute myocardial infarction, heart failure, coronary artery disease, diabetes, stroke, essential hypertension, and acute pulmonary embolism. In addition, the origin and function and the different strategies to identify circulating miRNAs as novel biomarkers for cardiovascular diseases are also discussed. Rarely has an opportunity arisen to advance such new biology for the diagnosis of cardiac diseases.

Keywords

MicroRNAs Plasma Serum Biomarker Cardiovascular diseases