Journal of Molecular Medicine

, Volume 89, Issue 8, pp 733–742

Peptide-MHC-based nanovaccines for the treatment of autoimmunity: a “one size fits all” approach?

  • Xavier Clemente-Casares
  • Sue Tsai
  • Yang Yang
  • Pere Santamaria
Review

DOI: 10.1007/s00109-011-0757-z

Cite this article as:
Clemente-Casares, X., Tsai, S., Yang, Y. et al. J Mol Med (2011) 89: 733. doi:10.1007/s00109-011-0757-z

Abstract

Nanotechnology offers enormous potential in drug delivery and in vivo imaging. Nanoparticles (NPs), for example, are being extensively tested as scaffolds to deliver anti-cancer therapeutics or imaging tags. Our recent work, discussed herein, indicates that an opportunity exists to use NPs to deliver ligands for, and trigger, cognate receptors on T lymphocytes as a way to induce therapeutic immune responses in vivo. Specifically, systemic delivery of NPs coated with Type 1 diabetes (T1D)-relevant peptide-major histocompatibility complex molecules triggered the expansion of cognate memory autoregulatory (disease-suppressing) T cells, suppressed the progression of autoimmune attack against insulin-producing beta cells, and restored glucose homeostasis. This therapeutic avenue exploits a new paradigm in the progression of chronic autoimmune responses that enables the rational design of disease-specific “nanovaccines” capable of blunting autoimmunity without impairing systemic immunity, a long sought-after goal in the therapy of these disorders. Here, we discuss the research paths that led to the discovery of this therapeutic avenue and highlight the features that make it an attractive approach for the treatment, in an antigen-specific manner, of a whole host of autoimmune diseases.

Keywords

AutoimmunityBeta cellsDiabetesImmune toleranceLymphocyte

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Xavier Clemente-Casares
    • 1
  • Sue Tsai
    • 1
  • Yang Yang
    • 1
  • Pere Santamaria
    • 1
  1. 1.Julia McFarlane Diabetes Research Centre and Department of Microbiology and Infectious Diseases, Institute of Inflammation, Infection and Immunity, Faculty of MedicineThe University of CalgaryCalgaryCanada