Journal of Molecular Medicine

, Volume 88, Issue 10, pp 1021–1027

Mitochondria and aging in the vascular system

  • Zoltan Ungvari
  • William E. Sonntag
  • Anna Csiszar
Review

DOI: 10.1007/s00109-010-0667-5

Cite this article as:
Ungvari, Z., Sonntag, W.E. & Csiszar, A. J Mol Med (2010) 88: 1021. doi:10.1007/s00109-010-0667-5

Abstract

This review focuses on mitochondrial abnormalities that occur in the vasculature during aging and explores the link between mitochondrial oxidative stress, chronic low-grade vascular inflammation, increased rate of endothelial apoptosis, and development of vascular diseases in the elderly. Therapeutic strategies targeting the mitochondria for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the vasoprotective effects of caloric restriction, caloric restriction mimetics, the GH/IGF-1 axis, and mitochondria-targeted antioxidants.

Keywords

AgingMitochondriaEndothelium

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Zoltan Ungvari
    • 1
  • William E. Sonntag
    • 1
  • Anna Csiszar
    • 1
  1. 1.Reynolds Oklahoma Center on Aging, Department of Geriatric MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA