, Volume 88, Issue 10, pp 1021-1027
Date: 17 Aug 2010

Mitochondria and aging in the vascular system

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


This review focuses on mitochondrial abnormalities that occur in the vasculature during aging and explores the link between mitochondrial oxidative stress, chronic low-grade vascular inflammation, increased rate of endothelial apoptosis, and development of vascular diseases in the elderly. Therapeutic strategies targeting the mitochondria for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the vasoprotective effects of caloric restriction, caloric restriction mimetics, the GH/IGF-1 axis, and mitochondria-targeted antioxidants.