Journal of Molecular Medicine

, Volume 88, Issue 9, pp 881–888

Mucosal control of the intestinal microbial community


DOI: 10.1007/s00109-010-0639-9

Cite this article as:
Brugman, S. & Nieuwenhuis, E.E.S. J Mol Med (2010) 88: 881. doi:10.1007/s00109-010-0639-9


Although the knowledge of the effects of bacterial colonization on the immune system is rapidly expanding, surprisingly little is known about the immunological mechanisms that shape the intestinal microbial community. Specifically, the complexity of the intestinal microbiota and what constitutes a “healthy” microbial composition has only recently been addressed, facilitated by large-scale metagenomic screens. Containment of such a vast number of different microbes requires tight regulation at the mucosal surface. While beneficial relationships must not be compromised, invading pathogenic bacteria must be dealt with in order to maintain homeostasis. In this review, we will address the latest insights into the role of the mucosal immune system in the control of the microbiota.


Mucosal immunology Bacteria Regulation CD1d Zebrafish enterocolitis IBD 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Pediatric Gastroenterology, Wilhelmina Children’s HospitalUniversity Medical Center UtrechtUtrechtNetherlands