Journal of Molecular Medicine

, Volume 88, Issue 9, pp 873-880

First online:

Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors

  • Ivan ZanoniAffiliated withDepartment of Biotechnology and Bioscience, University of Milano-Bicocca
  • , Francesca GranucciAffiliated withDepartment of Biotechnology and Bioscience, University of Milano-Bicocca Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.


Dendritic cells Toll-like receptors CD14 Innate immunity Apoptosis