Journal of Molecular Medicine

, Volume 88, Issue 2, pp 97–102

The pneumococcus: why a commensal misbehaves


DOI: 10.1007/s00109-009-0557-x

Cite this article as:
Weiser, J.N. J Mol Med (2010) 88: 97. doi:10.1007/s00109-009-0557-x


Several characteristics of Streptococcus pneumoniae (pneumococcus) combine to make it a particularly problematic pathogen. Firstly, the pneumococcus has the capacity to cause disease through the expression of virulence factors such as its polysaccharide capsule and pore-forming toxin. In addition, the pneumococcus is highly adaptable as demonstrated by its ability to acquire and disseminate resistance to multiple antibiotics. Although the pneumococcus is a major cause of disease, the organism is most commonly an “asymptomatic” colonizer of its human host (the carrier state), with transmission occurring exclusively from this reservoir of commensal organisms. Thus, it is unclear how the organism’s virulence and adaptability promote its persistence or host to host spread during its carrier state. This review summarizes current understanding of how these characteristics may contribute to the commensal lifestyle of the pneumococcus.


Colonization Virulence factor Neutrophil Pneumococcus 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Microbiology and PediatricsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.University of Pennsylvania School of MedicinePhiladelphiaUSA

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