Journal of Molecular Medicine

, Volume 87, Issue 7, pp 669–677

Anaplastic lymphoma kinase: an oncogene for tumor vaccination

  • Cristina Mastini
  • Cinzia Martinengo
  • Giorgio Inghirami
  • Roberto Chiarle
Review

DOI: 10.1007/s00109-009-0460-5

Cite this article as:
Mastini, C., Martinengo, C., Inghirami, G. et al. J Mol Med (2009) 87: 669. doi:10.1007/s00109-009-0460-5

Abstract

The immune system contributes both to the maintenance of cancer in an equilibrium state and to the elimination of tumor cells. Specific antitumor vaccination could increase the intensity or modulate the quality of this immune response against transformed cells. Antitumor vaccination strategies rely upon the identification of one or multiple antigens that can serve to stimulate the immune system. This review will focus particularly on cancer vaccination strategies based on the use of DNA molecules and on the search for antigens that are required for the growth of tumor cells and that cannot be easily down-regulated by the cancer cells (oncoantigens). In addition, we will summarize some results on clinical trials that are currently exploiting selected antigens against tumors and on the recently identified anaplastic lymphoma kinase as a potential oncoantigen for selected types of human cancers.

Keywords

Cancer vaccineDNA vaccinationTumor immunityAnaplastic lymphoma kinaseLymphomaLung carcinomaNeuroblastoma

Abbreviations

ALCL

Anaplastic large cell lymphomas

ALK

Anaplastic lymphoma kinase

ATIC

5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

CNS

Central nervous system

CTL

Cytotoxic T lymphocytes

DC

Dendritic cell

EML4

Echinoderm microtubule-associated protein-like 4

Her2

Human epidermal growth factor receptor 2

IFN-γ

Interferon-gamma

LTK

Leukocyte tyrosine kinase

MHC

Major histocompatibility complexes

MUC1

Mucin 1

NHL

Non-Hodgkin lymphomas

NPM1

Nucleophosmin

NSCLCs

Non-small-cell lung cancers

shRNA

Short hairpin RNA

siRNA

Small interfering RNA

TAAs

Tumor-associated antigens

TGF

Transforming growth factor

Th

T helper

TMP3

Tropomyosin

TYR

Tyrosinase

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Cristina Mastini
    • 1
  • Cinzia Martinengo
    • 1
  • Giorgio Inghirami
    • 1
    • 2
    • 3
    • 4
  • Roberto Chiarle
    • 1
    • 2
  1. 1.Center for Experimental Research and Medical Studies (CERMS)University of TurinTurinItaly
  2. 2.Department of Biomedical Sciences and Human OncologyUniversity of TurinTurinItaly
  3. 3.Department of PathologyNew York University School of MedicineNew YorkUSA
  4. 4.New York Cancer CenterNew York University School of MedicineNew YorkUSA