Journal of Molecular Medicine

, Volume 87, Issue 7, pp 663–668

The dysregulation of the endocannabinoid system in diabesity—a tricky problem

Review

DOI: 10.1007/s00109-009-0459-y

Cite this article as:
Scherer, T. & Buettner, C. J Mol Med (2009) 87: 663. doi:10.1007/s00109-009-0459-y

Abstract

Endocannabinoids (ECs) are small lipid mediators that play a critical role in energy metabolism. Human studies have shown that the EC tone in peripheral tissues positively correlates with increased adiposity. Furthermore, pharmacological inhibition of EC signaling results in weight loss in humans. However, the mechanisms that cause the dysregulation of the EC system in obesity are not well-understood. Since the clinical utility of currently available EC blockers is severely limited due to their side effects like depression and suicidal ideation that are caused by central effects, it is important to delineate the role of central and peripheral effects of EC signaling in regulating glucose and lipid metabolism.

Keywords

EndocannabinoidsLeptin actionAdipose tissueMediobasal hypothalamusFat metabolism

Abbreviations

2-AG

2-arachidonoylglycerol

ACC

acetyl-CoA carboxylase

AEA

anandamide

CNS

central nervous system

DM2

type 2 diabetes mellitus

ECs

endocannabinoids

FAAH

fatty acid amide hydrolase

FAS

fatty acid synthase

GLUT4

glucose transporter 4

HSL

hormone-sensitive lipase

ICV

intracerebroventricular

KO

knock-out

LCB1

hepatocyte-specific CB1 receptor knock-out

LPL

lipoprotein lipase

MBH

mediobasal hypothalamus

NE

norepinephrine

Pepck

phosphoenolpyruvate kinase

PPARγ

peroxisome proliferator-activated receptor γ

Srebp1c

sterol regulatory element-binding protein-1c

UCP2

uncoupling protein 2

WAT

white adipose tissue

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Medicine and NeuroscienceMount Sinai School of MedicineNew YorkUSA