Journal of Molecular Medicine

, Volume 87, Issue 5, pp 451–454

IL-22: A critical mediator in mucosal host defense

Review

DOI: 10.1007/s00109-009-0448-1

Cite this article as:
Aujla, S.J. & Kolls, J.K. J Mol Med (2009) 87: 451. doi:10.1007/s00109-009-0448-1

Abstract

IL-22 is an IL-10 family cytokine member that was recently discovered to be produced by Th17 cells. Current studies have revealed that IL-22 targets cells of the digestive, skin, and respiratory organ systems and plays an important role in mucosal immunity. The IL-22 receptor (IL-22R) is expressed exclusively in these tissues, thereby allowing the cytokine to mediate epithelial innate immunity in response to a variety of pathogens. Although recent studies have shown the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung), there is evidence that IL-22 also plays a role in autoimmune disease, such as psoriasis. IL-22 therefore, not unlike other cytokines, has complex pro-inflammatory, anti-inflammatory, and autoimmune effects which continue to be under further investigation. This review will focus on what is known about IL-22 and its function in mucosal host defense.

Keywords

IL-22Innate immunityAutoimmunity

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Division of Pulmonary Medicine, Allergy and ImmunologyChildren’s Hospital of PittsburghPittsburghUSA