Journal of Molecular Medicine

, Volume 86, Issue 6, pp 679–684

New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice

  • Xiao Z. Shen
  • Hong D. Xiao
  • Ping Li
  • Chentao X. Lin
  • Sandrine Billet
  • Derick Okwan-Duodu
  • Jon W. Adams
  • Ellen A. Bernstein
  • Yi Xu
  • Sebastien Fuchs
  • Kenneth E. Bernstein
Review

DOI: 10.1007/s00109-008-0325-3

Cite this article as:
Shen, X.Z., Xiao, H.D., Li, P. et al. J Mol Med (2008) 86: 679. doi:10.1007/s00109-008-0325-3

Abstract

Angiotensin-converting enzyme (ACE) has been well-recognized for its role in blood pressure regulation. ACE is made by many tissues, though it is most abundantly expressed on the luminal surface of vascular endothelium. ACE knockout mice show a profound phenotype with low blood pressure, but also with hemopoietic and developmental defects, which complicates understanding the biological functions of ACE in individual tissue types. Using a promoter-swapping strategy, several mouse lines with unique ACE tissue expression patterns were studied. These include mice with ACE expression in the liver (ACE 3/3), the heart (ACE 8/8), and macrophages (ACE 10/10). We also investigated mice with a selective inactivation of either the N- or C-terminal ACE catalytic domain. Our studies indicate that ACE plays a role in many other physiologic processes beyond simple blood pressure control.

Keywords

Angiotensin-converting enzyme Mice Gene targeting Tissue-specific expression Heart Macrophages 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Xiao Z. Shen
    • 1
  • Hong D. Xiao
    • 1
  • Ping Li
    • 1
  • Chentao X. Lin
    • 1
  • Sandrine Billet
    • 1
  • Derick Okwan-Duodu
    • 1
  • Jon W. Adams
    • 1
  • Ellen A. Bernstein
    • 1
  • Yi Xu
    • 1
  • Sebastien Fuchs
    • 1
  • Kenneth E. Bernstein
    • 1
  1. 1.Department of PathologyEmory UniversityAtlantaUSA