Journal of Molecular Medicine

, Volume 86, Issue 2, pp 135–144

Pericytes: gatekeepers in tumour cell metastasis?

Review

DOI: 10.1007/s00109-007-0258-2

Cite this article as:
Gerhardt, H. & Semb, H. J Mol Med (2008) 86: 135. doi:10.1007/s00109-007-0258-2

Abstract

Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.

Keywords

PericyteEndotheliumMetastasisNCAMPDGFB

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Vascular Biology LaboratoryLondon Research Institute—Cancer Research UKLondonUK
  2. 2.Stem Cell CenterLund UniversityLundSweden