Journal of Molecular Medicine

, Volume 85, Issue 6, pp 655–656

Activity of the Akt-dependent anabolic and catabolic pathways in muscle and liver samples in cancer-related cachexia

  • Thomas L. Schmitt
  • Marcus E. Martignoni
  • Jeannine Bachmann
  • Kerstin Fechtner
  • Helmut Fries
  • Ralf Kinscherf
  • Wulf Hildebrandt
Publisher´s Erratum

DOI: 10.1007/s00109-007-0206-1

Cite this article as:
Schmitt, T.L., Martignoni, M.E., Bachmann, J. et al. J Mol Med (2007) 85: 655. doi:10.1007/s00109-007-0206-1
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Erratum to: J Mol Med (2007) DOI 10.1007/s00109-007-0177-2

Unfortunately, Figs. 2, 3, 4 and 5 were printed with errors. The corrected figures are given here:
https://static-content.springer.com/image/art%3A10.1007%2Fs00109-007-0206-1/MediaObjects/109_2007_206_Fig1_HTML.gif
Fig. 2

Western blot analysis of Akt expression and phosphorylation in muscle biopsies of cachectic (+Cach.) and non-cachectic (−Cach.) patients. The blot shows representative lysates that were separated on a 9% SDS-PAA gel and stained with antibodies directed against all isoforms of Akt, pS473-Akt or pT308-Akt. In the lower panel, the percentage of relative protein level is reported as mean±SEM, where the value from non-cachectic subjects (control group) is set to 100%. **P ≤ 0.01

https://static-content.springer.com/image/art%3A10.1007%2Fs00109-007-0206-1/MediaObjects/109_2007_206_Fig2_HTML.gif
Fig. 3

Western blot analysis of expression and phosphorylation of Foxo proteins in muscle biopsies of cachectic (+Cach.) and non-cachectic (−Cach.) patients. The blot shows representative lysates that were separated on a 9% SDS-PAA gel and stained with antibodies directed against Foxo1 (FKHR), Foxo3a (FKHRL1) and pThr32-Foxo3a, respectively. In the lower panel, the percentage of relative protein level is reported as mean±SEM, where the value from non-cachectic subjects (control group) is set to 100%. **P ≤ 0.01

https://static-content.springer.com/image/art%3A10.1007%2Fs00109-007-0206-1/MediaObjects/109_2007_206_Fig3_HTML.gif
Fig. 4

Western blot analysis of mTOR expression and phosphorylation in muscle biopsies of cachectic (+Cach.) and non-cachectic (−Cach.) patients. Representative lysates were separated on a 7.5% SDS-PAA gel and stained with antibodies directed against mTOR and pS2448-mTOR. In the lower panel, the percentage of relative protein level is reported as mean±SEM, where the value from non-cachectic subjects as the control group is set to 100%. **P ≤ 0.01

https://static-content.springer.com/image/art%3A10.1007%2Fs00109-007-0206-1/MediaObjects/109_2007_206_Fig4_HTML.gif
Fig. 5

Western blot analysis of expression and phosphorylation of p70S6 kinase in muscle biopsies of cachectic (+Cach.) and non-cachectic (−Cach.) patients. The blot shows representative muscle lysates from muscle that were separated on a 9% PAA gel and probed with antibodies directed against S6K and pT389-S6K. In the lower panel, the percentage of relative protein level is reported as mean±SEM, where the value from non-cachectic subjects (control group) is set to 100%. *P ≤ 0.05

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Thomas L. Schmitt
    • 1
  • Marcus E. Martignoni
    • 2
  • Jeannine Bachmann
    • 2
  • Kerstin Fechtner
    • 3
  • Helmut Fries
    • 2
  • Ralf Kinscherf
    • 4
  • Wulf Hildebrandt
    • 1
  1. 1.Division of Immunochemistry (D020)German Cancer Research CenterHeidelbergGermany
  2. 2.Department of General SurgeryUniversity of HeidelbergHeidelbergGermany
  3. 3.Department of RadiologyUniversity of HeidelbergHeidelbergGermany
  4. 4.Anatomy and Developmental Biology, Medizinische Fakultät MannheimUniversity of HeidelbergHeidelbergGermany