Journal of Molecular Medicine

, Volume 85, Issue 8, pp 797–810

Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy

  • Ines Pagel-Langenickel
  • Jens Buttgereit
  • Michael Bader
  • Thomas H. Langenickel

DOI: 10.1007/s00109-007-0183-4

Cite this article as:
Pagel-Langenickel, I., Buttgereit, J., Bader, M. et al. J Mol Med (2007) 85: 797. doi:10.1007/s00109-007-0183-4


Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.


Cardiac hypertrophyNatriuretic peptide receptor BC-type natriuretic peptideCardiovascular



C-type natriuretic peptide


natriuretic peptide receptor B

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ines Pagel-Langenickel
    • 1
  • Jens Buttgereit
    • 2
  • Michael Bader
    • 2
  • Thomas H. Langenickel
    • 3
  1. 1.National Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaUSA
  2. 2.Max Delbrueck Center for Molecular Medicine Berlin-BuchBerlinGermany
  3. 3.Vascular Biology Section, Genome Technology BranchNational Human Genome Research Institute, National Institutes of HealthBethesdaUSA