Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy
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- Pagel-Langenickel, I., Buttgereit, J., Bader, M. et al. J Mol Med (2007) 85: 797. doi:10.1007/s00109-007-0183-4
Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.
KeywordsCardiac hypertrophyNatriuretic peptide receptor BC-type natriuretic peptideCardiovascular
C-type natriuretic peptide
natriuretic peptide receptor B