Bmi1 in development and tumorigenesis of the central nervous system
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- Shakhova, O., Leung, C. & Marino, S. J Mol Med (2005) 83: 596. doi:10.1007/s00109-005-0682-0
The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesis.