Journal of Molecular Medicine

, Volume 83, Issue 8, pp 596–600

Bmi1 in development and tumorigenesis of the central nervous system

Review

DOI: 10.1007/s00109-005-0682-0

Cite this article as:
Shakhova, O., Leung, C. & Marino, S. J Mol Med (2005) 83: 596. doi:10.1007/s00109-005-0682-0

Abstract

The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesis.

Keywords

Bmi1CerebellumMedulloblastomaNeural stem cells

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Institute of Clinical PathologyUniversity HospitalZürichSwitzerland