Journal of Molecular Medicine

, Volume 83, Issue 9, pp 657–671

Molecular targets in spinal cord injury

Review

DOI: 10.1007/s00109-005-0663-3

Cite this article as:
Klussmann, S. & Martin-Villalba, A. J Mol Med (2005) 83: 657. doi:10.1007/s00109-005-0663-3

Abstract

The spinal cord can be compared to a highway connecting the brain with the different body levels lying underneath, with the axons being the ultimate carriers of the electrical impulse. After spinal cord injury (SCI), many cells are lost because of the injury. To reconstitute function, damaged axons from surviving neurons have to grow through the lesion site to their initial targets. However, the territory they have to traverse has changed: the highway is full of inhibitory signals (myelin and scar components); the pavement itself has become bumpy (demyelination); and specialized cells are recruited to clear the way (inflammatory cells). Thus, actual strategies to treat spinal injuries aim at providing a permissive environment for regenerating axons and boosting the endogenous potential of axons to regenerate while limiting progression of secondary damage. Here we review some of the strategies currently under consideration to treat spinal injuries.

Keywords

Spinal traumaNeuroprotective strategiesMolecular targetsApoptosisMyelinConcomitant function

Abbreviations

SCI

Spinal cord injury

ATP

Adenosine triphosphate

NMDA

N-methyl-d-aspartate

AMPA

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

NASCIS

National Acute Spinal Cord Injury Study

NO

Nitric oxide

NOS

Nitric oxide synthase

4-AP

4-Aminopyridine

MP

Methylprednisolone

MMP

Matrix metalloprotease

ICAM-1

Intercellular adhesion molecule-1

VCAM-1

Vascular cell adhesion molecule-1

TNF

Tumor necrosis factor

IL

Interleukin

PG

Prostaglandin

COX

Cyclooxygenase

MBP

Myelin basic protein

zVAD-fmk

N-Benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone

p75NTR

p75 neurotrophin receptor

CD95L

CD95 ligand

BBB

Blood–brain barrier

CSPGs

Chondroitin sulfate proteoglycans

OMgp

Oligodendrocyte myelin glycoprotein

MAG

Myelin-associated glycoprotein

NgR

Nogo receptor

ROCK

RhoA-associated kinase

OECs

Olfactory ensheathing cells

OPCs

Oligodendrocyte precursor cells

MS

Multiple sclerosis

DRG

Dorsal root ganglion

cAMP

Cyclic adenosine monophosphate

PKA

Protein kinase-A

BDNF

Brain-derived neurotrophic factor

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Tumorimmunology Program, Division of ImmunogeneticsGerman Cancer Research CenterHeidelbergGermany