Journal of Molecular Medicine

, Volume 83, Issue 3, pp 193–202

The balance of immune responses: costimulation verse coinhibition

  • Sumit K. Subudhi
  • Maria-Luisa Alegre
  • Yang-Xin Fu
Review

DOI: 10.1007/s00109-004-0617-1

Cite this article as:
Subudhi, S.K., Alegre, ML. & Fu, YX. J Mol Med (2005) 83: 193. doi:10.1007/s00109-004-0617-1

Abstract

Many of the B7 superfamily members (e.g., B7-1, B7-2, ICOS-L, B7-H1, B7-DC) were initially characterized as T cell costimulatory molecules. However, more recently it has become clear they can also coinhibit T cell responses. We review many of the B7 family members, with a particular focus on B7-H1, and examine their role in autoimmunity, transplant rejection, and cancer pathogenesis. It is crucial to understand that many B7 family members have opposing effects on an immune response. This cautions against using clinical immunotherapeutic reagents targeted against these molecules until we gain a better understanding of the circumstances that regulate the outcomes of the T cell response.

Keywords

Costimulation Coinhibition Lymphocytes B7 family 

Abbreviations

CTLA

Cytotoxic T lymphocyte antigen

EAE

Experimental autoimmune encephalomyelitis

ICOS

Inducible costimulator

ICOS-L

Ligand for inducible costimulator

ITIM

Immunoreceptor tyrosine-based inhibitory motif

ITSM

Immunoreceptor tyrosine-based switch motif

mAb

Monoclonal antibody

SH

Src homology

SHIP

SH2-containing inositol phosphatase

SHP

SH2-containing tyrosine phosphatase

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Sumit K. Subudhi
    • 1
    • 3
  • Maria-Luisa Alegre
    • 2
    • 3
  • Yang-Xin Fu
    • 1
    • 3
  1. 1.Department of PathologyUniversity of ChicagoChicagoUSA
  2. 2.Department of MedicineUniversity of ChicagoChicagoUSA
  3. 3.Committee on ImmunologyUniversity of ChicagoChicagoUSA

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