Journal of Molecular Medicine

, Volume 82, Issue 9, pp 558–564

SLC22A4 and RUNX1: identification of RA susceptible genes

  • Ryo Yamada
  • Shinya  Tokuhiro
  • Xiotian Chang
  • Kazuhiko Yamamoto
Review

DOI: 10.1007/s00109-004-0547-y

Cite this article as:
Yamada, R., Tokuhiro, S., Chang, X. et al. J Mol Med (2004) 82: 558. doi:10.1007/s00109-004-0547-y

Abstract

Recently we reported that SLC22A4 and RUNX1 are associated with rheumatoid arthritis (RA). SLC22A4 is an organic cation transporter with unknown physiological function, and RUNX1 is a hematological transcriptional regulator that has been shown to be responsible for acute myelogenic leukemia. It is suggested that the association of RUNX1 with RA is due to its regulation of expression of SLC22A4. Because the physiological function of SLC22A4 is still unclear, further investigation is needed into how SLC22A4 affects RA susceptibility. Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases.

Keywords

Rheumatoid arthritisSLC22A4RUNX1

Abbreviations

CBF

Core-binding factor

IL

Interleukin

IRF

Interferon regulatory factor

LD

Linkage disequilibrium

NCF

Neutrophil cytosolic factor

OCT

Organic cation transporter

PADI

Peptidylarginine deiminase

RA

Rheumatoid arthritis

SLE

Systemic lupus erythematosus

SNP

Single nucleotide polymorphism

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Ryo Yamada
    • 1
  • Shinya  Tokuhiro
    • 1
  • Xiotian Chang
    • 1
  • Kazuhiko Yamamoto
    • 1
  1. 1.Laboratory for Rheumatic Diseases, SNP Research CenterInstitute of Physical and Chemical ResearchYokohama, KanagawaJapan