Journal of Molecular Medicine

, Volume 81, Issue 11, pp 700–707

BRCA1 and p53: compensatory roles in DNA repair

Authors

  • Anne-Renee Hartman
    • Departments of Medicine (Oncology) and Genetics, School of MedicineStanford University
    • Dana Farber Cancer Institute
    • Departments of Medicine (Oncology) and Genetics, School of MedicineStanford University
Invited Review

DOI: 10.1007/s00109-003-0477-0

Cite this article as:
Hartman, A. & Ford, J.M. J Mol Med (2003) 81: 700. doi:10.1007/s00109-003-0477-0

Abstract

The BRCA1 breast cancer susceptibility gene has been implicated in many cellular processes, yet its specific mechanism of tumor suppression remains unclear. BRCA1 plays a role in several DNA repair pathways including nucleotide excision repair (NER). Loss of the p53 tumor suppressor gene, a key regulator of NER, is an important and necessary event in the pathogenesis of BRCA1-mutated tumors. Here we discuss the role of BRCA1 and NER in breast cancer and the interactions of BRCA1 with p53 in breast tumorigenesis and suggest approaches for risk assessment and chemotherapeutic management of BRCA1-related breast cancer.

Keywords

BRCA1p53Nucleotide excision repairBreast cancer

Abbreviations

BPDE

Benzo[a]pyrene-7,8-diol-9,10-epoxide

ER

Estrogen receptor

FA

Fanconi anemia

GGR

Global genomic repair

IR

Ionizing radiation

NER

Nucleotide excision repair

TCR

Transcription-coupled repair

UV

Ultraviolet

XP

Xeroderma pigmentosum

Copyright information

© Springer-Verlag 2003