Journal of Molecular Medicine

, Volume 80, Issue 12, pp 791–795

The K121Q polymorphism in the plasma cell membrane glycoprotein 1 gene predisposes to early myocardial infarction

  • Georg Endler
  • Christine Mannhalter
  • Heike Sunder-Plassmann
  • Martin Schillinger
  • Alexandra Klimesch
  • Markus Exner
  • Sonja Kapiotis
  • Susanne Meier
  • Freja Kunz
  • Elisabeth Raiger
  • Kurt Huber
  • Oswald Wagner
  • Raute Sunder-Plassmann
Original Article

DOI: 10.1007/s00109-002-0385-8

Cite this article as:
Endler, G., Mannhalter, C., Sunder-Plassmann, H. et al. J Mol Med (2002) 80: 791. doi:10.1007/s00109-002-0385-8

Abstract.

Elevated plasma cell membrane glycoprotein 1 (PC-1) expression and the frequent PC-1 K121Q polymorphism have recently been associated with insulin resistance. Since insulin resistance represents an important risk factor for atherosclerotic vascular disease and myocardial infarction, we investigated the involvement of the PC-1 K121Q polymorphism in the development of myocardial infarction. We analyzed two independent series of cardiovascular patients at a defined end-point of atherosclerotic vascular disease (those having suffered myocardial infarction) for the PC-1 K121Q mutation by a newly developed mutagenic separated PCR assay. In both patient groups the presence of the Q allele was significantly associated with younger age at the time of first myocardial infarction, suggesting a more rapid progression of endothelial dysfunction. In a multivariate analysis carriers of the 121Q allele from Vienna and from Central Germany exhibited a 2.6- and a 4.2-increased odds, respectively, for suffering myocardial infarction within the first tertile of age (<51 and <48 years, respectively). Our data indicate that the PC-1 121Q allele might predispose independently of other well established risk factors for early myocardial infarction. Testing for the PC-1 K121Q polymorphism might be valuable in patients with a family history of atherosclerotic vascular disease and myocardial infarction.

Plasma cell membrane glycoprotein 1 Polymorphism Myocardial infarction Insulin resistance

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Georg Endler
    • 1
  • Christine Mannhalter
    • 1
  • Heike Sunder-Plassmann
    • 1
  • Martin Schillinger
    • 2
  • Alexandra Klimesch
    • 1
  • Markus Exner
    • 1
  • Sonja Kapiotis
    • 1
  • Susanne Meier
    • 1
  • Freja Kunz
    • 1
  • Elisabeth Raiger
    • 1
  • Kurt Huber
    • 3
  • Oswald Wagner
    • 1
  • Raute Sunder-Plassmann
    • 1
  1. 1.Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Biology, General Hospital of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria
  2. 2.Department of Internal Medicine II, Division of Angiology, General Hospital of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria
  3. 3.Department of Internal Medicine II, Division of Cardiology, General Hospital of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria