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Herpes zoster nach Varicella-Zoster-Virus-Impfung

Herpes zoster after varicella-zoster vaccination

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Zusammenfassung

Ein 5-jähriges gegen Varizella-Zoster-Virus (VZV) geimpftes Mädchen stellte sich mit der Klinik eines Herpes Zoster C6 vor. Ein VZV-Direktnachweis fiel trotz Entnahme von ausreichend Zellmaterial aus frischen Blasen 3-fach negativ aus. Erst eine ergänzende genotypische Analyse zeigte einen VZV-Stamm des Genotyps 2 (Oka-Impfstamm), sodass die seltene Diagnose eines Impfzosters gestellt wurde. Die Patientin erhielt eine entsprechende Therapie, ein Immundefekt wurde ausgeschlossen. Dieser Fall zeigt, dass ein negativer VZV-Direktnachweis keineswegs das Vorliegen eines Impfzosters ausschließt.

Abstract

A five-year-old girl, vaccinated against varicella-zoster virus (VZV) presented with clinical symptoms of herpes zoster in the 6th cervical dermatome. A VZV direct immune-fluorescence assay was negative three times but additional genotypical analysis showed a VZV strain genotype 2 (Oka vaccine strain). Therefore the diagnosis of a breakthrough varicella disease with the vaccine strain was established. An immunodeficiency was ruled out and the patient responded well to the initiated therapy. This case demonstrates that a negative VZV direct immunofluorescence assay does not exclude an infection with the vaccine strain.

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  1. HELIOS Klinikum Wuppertal, Heusnerstr. 40, 42283, Wuppertal, Deutschland

    M. Fahlbusch, U. Wesselmann & P. Lehmann

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  1. M. Fahlbusch
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  2. U. Wesselmann
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  3. P. Lehmann
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Correspondence to M. Fahlbusch.

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Fahlbusch, M., Wesselmann, U. & Lehmann, P. Herpes zoster nach Varicella-Zoster-Virus-Impfung. Hautarzt 64, 107–109 (2013). https://doi.org/10.1007/s00105-012-2477-x

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