Comparison of two different matrix-based autologous chondrocyte transplantation systems: 1 year follow-up results
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The treatment of full-thickness cartilage defects of the knee is a common problem in orthopaedic surgery. Autologous chondrocyte transplantation (ACT) is one of the few reliable treatment options of cartilage defects with good long-term outcomes. The improvement of ACT led to the matrix-based ACT (MACT). The purpose of the study was to compare two different commercially available MACT systems.
Eleven patients with a cartilage defect of the knee were treated with the MACI® system and another nine patients with the CaRes® implant. The patients were prospectively followed and re-examined after one year.
One year after surgery all but one patient have significantly improved in their clinical outcome. Both types of MACT revealed similar results in terms of increase in level of activity, pain relief and knee function.
The study showed that MACT is a good therapeutic option for full-size defects of the femoral condyle. The MACI® implant seems to be easier to handle which is reflected by smaller incisions and a shorter operation time.
- Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331(14):889–95. CrossRef
- Bentley G, Biant LC, Carrington RW, Akmal M, Goldberg A, Williams AM, et al. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br. 2003;85(2):223–30. CrossRef
- Horas U, Pelinkovic D, Herr G, Aigner T, Schnettler R. Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial. J Bone Joint Surg Am. 2003;85-A(2):185–92.
- Peterson L, Minas T, Brittberg M, Lindahl A. Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am. 2003;85-A(Suppl 2):17–24.
- Gooding CR, Bartlett W, Bentley G, Skinner JA, Carrington R, Flanagan A. A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: periosteum covered versus type I/III collagen covered. Knee. 2006;13(3):203–10. CrossRef
- Minas T. Autologous chondrocyte implantation for focal chondral defects of the knee. Clin Orthop Relat Res. 2001;391(Suppl):S349–61. CrossRef
- Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res. 2000;374:212–34. CrossRef
- Bartlett W, Skinner JA, Gooding CR, Carrington RW, Flanagan AM, Briggs TW, et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg Br. 2005;87(5):640–5. CrossRef
- Ruano-Ravina A, Jato Diaz M. Autologous chondrocyte implantation: a systematic review. Osteoarthritis Cartilage. 2006;14(1):47–51. CrossRef
- Behrens P, Bosch U, Bruns J, Erggelet C, Esenwein SA, Gaissmaier C, et al. Indications and implementation of recommendations of the working group “tissue regeneration and tissue substitutes” for autologous chondrocyte transplantation (act). Z Orthop Ihre Grenzgeb. 2004;142(5):529–39. CrossRef
- Irrgang JJ, Anderson AF, Boland AL, Harner CD, Kurosaka M, Neyret P, et al. Development and validation of the international knee documentation committee subjective knee form. Am J Sports Med. 2001;29(5):600–13.
- Tegner Y, Lysholm J. Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res. 1985;198:43–9.
- ICRS. Cartilage evaluation package. In: package/ICRS evaluation.pdf. 2000. http://www.cartilage.org/Evaluation.
- Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, et al. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008;36(2):235–46. CrossRef
- Selmi TA, Verdonk P, Chambat P, Dubrana F, Potel JF, Barnouin L, et al. Autologous chondrocyte implantation in a novel alginate–agarose hydrogel: outcome at two years. J Bone Joint Surg Br. 2008;90(5):597–604. CrossRef
- Maus U, Schneider U, Gravius S, Muller-Rath R, Mumme T, Miltner O, et al. Clinical results after three years use of matrix-associated act for the treatment of osteochondral defects of the knee. Z Orthop Unfall. 2008;146(1):31–7. CrossRef
- Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (mact/maci)–5 year follow-up. Knee. 2006;13(3):194–202. CrossRef
- Marcacci M, Zaffagnini S, Kon E, Visani A, Iacono F, Loreti I. Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc. 2002;10(3):154–9. CrossRef
- Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R. Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol. 2006;57(1):3–8. CrossRef
- Steinwachs M, Kreuz PC. Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: a prospective study with a 3 year follow-up. Arthroscopy. 2007;23(4):381–7. CrossRef
- Kon E, Gobbi A, Filardo G, Delcogliano M, Zaffagnini S, Marcacci M. Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective non-randomized study at 5 years. Am J Sports Med. 2009;37(1):33–41. CrossRef
- Concaro S, Nicklasson E, Ellowsson L, Lindahl A, Brittberg M, Gatenholm P. Effect of cell seeding concentration on the quality of tissue engineered constructs loaded with adult human articular chondrocytes. J Tissue Eng Regen Med. 2008;2(1):14–21. CrossRef
- Dowthwaite GP, Bishop JC, Redman SN, Khan IM, Rooney P, Evans DJ, et al. The surface of articular cartilage contains a progenitor cell population. J Cell Sci. 2004;117(Pt 6):889–97. CrossRef
- Gigante A, Bevilacqua C, Zara C, Travasi M, Chillemi C. Autologous chondrocyte implantation: cells phenotype and proliferation analysis. Knee Surg Sports Traumatol Arthrosc. 2001;9(4):254–8. CrossRef
- Gigante A, Bevilacqua C, Ricevuto A, Mattioli-Belmonte M, Greco F. Membrane-seeded autologous chondrocytes: cell viability and characterization at surgery. Knee Surg Sports Traumatol Arthrosc. 2007;15(1):88–92. CrossRef
- Brittberg M, Sjogren-Jansson E, Lindahl A, Peterson L. Influence of fibrin sealant (tisseel) on osteochondral defect repair in the rabbit knee. Biomaterials. 1997;18(3):235–42. CrossRef
- Gille J, Meisner U, Ehlers EM, Muller A, Russlies M, Behrens P. Migration pattern, morphology and viability of cells suspended in or sealed with fibrin glue: a histomorphologic study. Tissue Cell. 2005;37(5):339–48. CrossRef
- Marlovits S, Striessnig G, Kutscha-Lissberg F, Resinger C, Aldrian SM, Vecsei V, et al. Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle. Knee Surg Sports Traumatol Arthrosc. 2005;13(6):451–7. CrossRef
- Sha′ban M, Kim SH, Idrus RB, Khang G. Fibrin and poly (lactic-co-glycolic acid) hybrid scaffold promotes early chondrogenesis of articular chondrocytes: an in vitro study. J Orthop Surg. 2008;3:17. CrossRef
- Ronga M, Grassi FA, Bulgheroni P. Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee. Arthroscopy. 2004;20(1):79–84. CrossRef
- Marcacci M, Kon E, Zaffagnini S, Filardo G, Delcogliano M, Neri MP, et al. Arthroscopic second generation autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc. 2007;15(5):610–9. CrossRef
- Wasiak J, Clar C, Villanueva E. Autologous cartilage implantation for full thickness articular cartilage defects of the knee. Cochrane Database Syst Rev. 2006;3:CD003323.
- Comparison of two different matrix-based autologous chondrocyte transplantation systems: 1 year follow-up results
European Journal of Trauma and Emergency Surgery
Volume 37, Issue 4 , pp 397-403
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Cartilage defect
- Autologous chondrocyte transplantation
- Matrix-based autologous chondrocyte transplantation
- Author Affiliations
- 1. Department of Trauma and Hand Surgery, Heinrich Heine University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany
- 2. Department of Arthroscopic Surgery and Sports Traumatology, Sankt Josef Orthopaedic and Rheumatology Centre Wuppertal, Wuppertal, Germany
- 3. Department of Surgery, St. Johannes-Hospital Varel, Varel, Germany