, Volume 21, Issue 1, pp 41-42

Comment on: Use of MR Venography for Characterization of the Extracranial Venous System in Patients with Multiple Sclerosis and Healthy Control Subjects

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Is Multiple Sclerosis a Disease of the Cerebrospinal Venous Outflow System?

In their paper “Use of MR Venography for Characterization of the Extracranial Venous System in Patients with Multiple Sclerosis and Healthy Control Subjects”, published in Radiology, Zivadinov et al. [1] report no significant differences in morphologic features of flow in the internal jugular veins and vertebral veins between multiple sclerosis (MS) patients and healthy control (HC) subjects in any magnetic resonance imaging (MRI) venographic parameter. A total of 57 patients including 41 (72%) with relapsing-remitting MS, 16 (28%) with secondary progressive MS and 21 HC subjects were imaged with a 3-Tesla MRI unit using two-dimensional (2D) time-of-flight (TOF) and three-dimensional (3D) time-resolved imaging of contrast kinetics (TRICKS) sequences. Additionally, 6 MS patients and 6 HC subjects underwent two MRI venographic examinations during 1 week to assure image-reimage reproducibility.

Multiple sclerosis is