, Volume 23, Issue 3, pp 1569-1580
Date: 04 Sep 2013

Eco-friendly synthesis and antimicrobial activities of substituted-5-(1H-indol-3-yl)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives

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l-Tyrosine is an efficient catalyst for the condensation of substituted indole-3-aldehydes 1(ad), N-methyl indole-3-aldehydes 4(a–d), and N-ethyl indole-3-aldehydes 6(a–d) with meldrum’s acid (2) containing a cyclic active methylene group to produce 3(ad), 5(ad), and 7(ad), respectively, in water at room temperature for 30 min. The antimicrobial activities of 3(ad), 5(ad), and 7(ad) have been studied.