Medicinal Chemistry Research

, Volume 22, Issue 1, pp 1–15

Vasicine and structurally related quinazolines

  • Kunal Nepali
  • Sahil Sharma
  • Ritu Ojha
  • Kanaya Lal Dhar
Review Article

DOI: 10.1007/s00044-012-0002-5

Cite this article as:
Nepali, K., Sharma, S., Ojha, R. et al. Med Chem Res (2013) 22: 1. doi:10.1007/s00044-012-0002-5

Abstract

Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.

Keywords

QuinazolineAntitussiveSynthesisBronchodilatorAlkaloid

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Kunal Nepali
    • 1
  • Sahil Sharma
    • 1
  • Ritu Ojha
    • 1
  • Kanaya Lal Dhar
    • 2
  1. 1.Department of Pharmaceutical SciencesGuru Nanak Dev UniversityAmritsarPunjab
  2. 2.Laboratory for Drug Design and Synthesis, Department of Pharmaceutical ChemistryIndo-Soviet Friendship (ISF) College of PharmacyMogaIndia