Medicinal Chemistry Research

, Volume 21, Issue 6, pp 722–725

Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor

  • Zhong-duo Yang
  • Dong-bo Zhang
  • Jin Ren
  • Ming-jun Yang
Original Research

DOI: 10.1007/s00044-011-9581-9

Cite this article as:
Yang, Z., Zhang, D., Ren, J. et al. Med Chem Res (2012) 21: 722. doi:10.1007/s00044-011-9581-9

Abstract

Skimmianine (1), a newly discovered strong acetylcholinesterase (AChE) inhibitor, along with nine weakly or no active compounds, toddalolactone (2), dictamnine (3), γ-fagarine (4), magnolone (5), (−)-(S)-edulinine (6), zanthodioline (7), edulitine (8), 5,6,7-trimethoxycoumarin (9), and haplopine (10) have been isolated from Zanthoxylum nitidum (Z. nitidum). Skimmianine (1) inhibited 50% of AChE activity at the concentrations of 8.6 ± 0.7 μg/ml when the IC50 value of Physostigmine as a standard was 0.013 ± 0.002 μg/ml. Antiacetylcholinesterase activity of skimmianine (1) was also supported by TLC bioautographic assay. The structure activity relationship on the anti-acetylcholinesterase activity of the quinoline moiety is also discussed in this article.

Keywords

Zanthoxylum nitidumSkimmianineAcetylcholinesterase inhibitorQuinoline alkaloidAlzheimer’s disease

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Zhong-duo Yang
    • 1
  • Dong-bo Zhang
    • 1
  • Jin Ren
    • 1
  • Ming-jun Yang
    • 1
  1. 1.School of Life Science and EngineeringLanzhou University of TechnologyLanzhouPeople’s Republic of China