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Efficient synthesis of antihistamines clocinizine and chlorcyclizine

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Abstract

A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine (8), is prepared from (4-chlorophenyl) (phenyl)-methanone (5), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily.

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Fig. 1
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Acknowledgments

One of the authors, PN is thankful to CSIR-New Delhi for providing with fellowship.

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Authors and Affiliations

  1. Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India

    A. Venkat Narsaiah & P. Narsimha

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  1. A. Venkat Narsaiah
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  2. P. Narsimha
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Correspondence to A. Venkat Narsaiah.

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Venkat Narsaiah, A., Narsimha, P. Efficient synthesis of antihistamines clocinizine and chlorcyclizine. Med Chem Res 21, 538–541 (2012). https://doi.org/10.1007/s00044-011-9556-x

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