Medicinal Chemistry Research

, Volume 21, Issue 4, pp 468–476

Synthesis, characterization, and antimicrobial activity of some new coumarin derivatives

Authors

  • Asma’a A. Al-Rifai
    • Department of Chemistry, Faculty of ScienceThe Hashemite University
  • Mikdad T. Ayoub
    • Department of Chemistry, Faculty of ScienceThe Hashemite University
  • Ashok K. Shakya
    • Faculty of Pharmacy and Medical SciencesAl-Ahliyya Amman University
  • Kayed A. Abu Safieh
    • Department of Chemistry, Faculty of ScienceThe Hashemite University
    • Department of ChemistryThe University of Jordan
Original Research

DOI: 10.1007/s00044-011-9553-0

Cite this article as:
Al-Rifai, A.A., Ayoub, M.T., Shakya, A.K. et al. Med Chem Res (2012) 21: 468. doi:10.1007/s00044-011-9553-0

Abstract

A number of new [(4-methyl-2-oxo-2H-chromen-7-yl)amino]methylcoumarins (5ac), benzofuran (6), and benzoxazol (7) were synthesized through the reaction of 7-amino-4-methylcoumarin (1) with a number of organic halides. In addition, series of N-substituted 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetohydrazide (11ah) and (12ad) were prepared from the reaction of 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetohydrazide (8) with corresponding heteroaryl/alkyl halides (24, 9, and 10). The synthesized compounds were characterized by elemental analysis and by spectroscopic techniques such as 1H-NMR, 13C-NMR, and mass spectrometry and were tested for their in vitro antimicrobial activity. The newly synthesized compounds exerted significant inhibitory activity against the growth of tested bacterial strains and a few of them are found to be potent antimicrobial agents.

Keywords

7-Amino-4-methylcoumarin Acetohydrazide Spectral analysis Antimicrobial activity

Copyright information

© Springer Science+Business Media, LLC 2011