Abstract
α-Glucosidase inhibition and DPPH free radical scavenging by 5-bromosalicylaldehyde and some Schiff bases have been measured. 5-Bromosalicylaldehyde shows lowest IC50 value (8.80 μM) for α-glucosidase inhibition and also shows good results in in vivo experiments for antihyperglycemic potential.
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Acknowledgments
The authors thank Dr. J. S. Yadav, the Director, Indian Institute of Chemical Technology, Hyderabad, for providing necessary facilities for biological activity screening and evaluation of the compounds presented in this report, Director Central Drug Research Institute, Lucknow, for elemental analysis, IR and NMR data and the University Grants Commission, New Delhi, for financial assistance in the form of a research project (F. No. 31-109/2005(SR)).
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Misra, S., Pandeya, K.B., Tiwari, A.K. et al. Antihyperglycemic, α-glucosidase inhibitory and DPPH free radical scavenging activity of 5-bromosalicylaldehyde and schiff bases. Med Chem Res 20, 1431–1437 (2011). https://doi.org/10.1007/s00044-010-9377-3
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DOI: https://doi.org/10.1007/s00044-010-9377-3