Chemical characterization and synergistic antibiotic activity of volatile compounds from the essential oil of Vanillosmopsis arborea
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- Santos, N.K.A., Coutinho, H.D.M., Viana, G.S.B. et al. Med Chem Res (2011) 20: 637. doi:10.1007/s00044-010-9372-8
Essential oils have been traditionally used for respiratory tract infections, and are used nowadays as ethnic medicines for colds. The objective of this work was to study the antibiotic-modifying activity of the essential oil from the leaves of Vanillosmopsis arborea Baker using gaseous contact. Stems of Vanillosmopsis arborea Baker (Asteracea) were subjected to hydrodistillation, and the essential oil extracted was evaluated for antibacterial and antibiotic-modifying activity by gaseous contact. The volatile components of the oil enhanced the sensitivity of Staphylococcus aureus ATCC 12692 and Proteus vulgaris ATCC 13315 to two or more antibiotics assayed. The activity of the antibiotic gentamicin was increased only in S. aureus. The activity of tetracycline and tobramycin was enhanced against both strains. The essential oil of Vanillosmopsis arborea influences the activity of antibiotics and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.