Medicinal Chemistry Research

, Volume 19, Issue 8, pp 771–781

Pharmacological characteristics of some 3-salicylidenehydrazono-2-indolinone coordination compounds

Original Research

DOI: 10.1007/s00044-009-9229-1

Cite this article as:
Konstantinović, S.S. & Cakić, V.S. Med Chem Res (2010) 19: 771. doi:10.1007/s00044-009-9229-1

Abstract

3-Salicylidenehydrazono-2-indolinone (SHI) complexes with Co(II), Ni(II), Cu(II), Zn(II), and Pd(II) were synthesized. All compounds were evaluated for their antimicrobial activity against seven pathogenic bacteria and four fungi. The compounds also have been screened for anti-inflammatory activity. The complexes have better antimicrobial and anti-inflammatory than ligand itself. The in vitro antiamoebic activity was evaluated against the HM1:IMSS strain of Entamoeba histolytica, and the results were compared with the standard drug, metronidazole. The preliminary test results showed that the complexes had better antiamoebic activity than their respective ligands. SHI and its complexes were found to possess potent antioxidant activity and be better than standard antioxidants, such as vitamin C and mannitol. In particular, the Cu(II) complex displayed excellent activity on the superoxide radical.

Keywords

IsatinSchiff baseComplexAntibacterial activityAntifungal activityAnti-inflammatory activityAntiamoebic activityAntioxidant activity

Copyright information

© Birkhäuser Boston 2009

Authors and Affiliations

  1. 1.Faculty of TechnologyLeskovacSerbia
  2. 2.Institute of Public HealthLeskovacSerbia