, Volume 17, Issue 2-7, pp 369-373

Synthesis of a novel barbiturate from 1-chloro-2,4-dinitrobenzene as an anticonvulsant agent

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Abstract

A new barbiturate has been synthesized from the ethanolic solution of 1-chloro-2,4-dinitrobenzene, barbituric acid, and triethylamine. The structure of the isolated molecule has been confirmed by ultraviolet (UV)-visible (VIS), infrared (IR), proton magnetic resonance (PMR), 13 C nuclear magnetic resonance (NMR), correlation spectroscopy (COSY) and mass spectrometry (MS) spectral studies. Elemental analysis and other qualitative tests have also been carried out to elucidate the proposed structure. The anticonvulsant activity of the synthesized molecule was tested by the maximal electro shock method. Albino rats of either sex weighing 150–200 g were used for the study. The drug was given 1h before the induction of maximal electro shock test. The different stages of convulsions such as tonic flexor, tonic extensor, clonus convulsion, stupor, and recovery/death were examined. Reduction in the extensor phase of convulsion was noted for the synthesized barbiturate.