, Volume 17, Issue 2-7, pp 326-334
Date: 29 Dec 2007

Amino steroids as antimalarial agents

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Abstract

Using easily accessible deoxycholic acid as the starting material, amino compounds 8a-e and 9a-c were prepared and screened against P. falciparum in vitro. Amino steroid 8d was the most active of the series with a minimum inhibiting concentration (MIC) of 0.5 μg/mL.