Medicinal Chemistry Research

, Volume 17, Issue 2, pp 326–334

Amino steroids as antimalarial agents

  • Upasana Sharma
  • Kumkum Srivastava
  • Sunil K. Puri
  • Chandan Singh
Original Research

DOI: 10.1007/s00044-007-9068-x

Cite this article as:
Sharma, U., Srivastava, K., Puri, S.K. et al. Med Chem Res (2008) 17: 326. doi:10.1007/s00044-007-9068-x

Abstract

Using easily accessible deoxycholic acid as the starting material, amino compounds 8a-e and 9a-c were prepared and screened against P. falciparum in vitro. Amino steroid 8d was the most active of the series with a minimum inhibiting concentration (MIC) of 0.5 μg/mL.

Keywords

Malaria Antimalarials Sarachine Deoxycholic acid Amino steroids 

Copyright information

© Birkha¨user Boston 2007

Authors and Affiliations

  • Upasana Sharma
    • 1
  • Kumkum Srivastava
    • 2
  • Sunil K. Puri
    • 2
  • Chandan Singh
    • 1
  1. 1.Division of Medicinal & Process ChemistryCentral Drug Research InstituteLucknowIndia
  2. 2.Division of ParasitologyCentral Drug Research InstituteLucknowIndia

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