Amino steroids as antimalarial agents
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- Sharma, U., Srivastava, K., Puri, S.K. et al. Med Chem Res (2008) 17: 326. doi:10.1007/s00044-007-9068-x
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Using easily accessible deoxycholic acid as the starting material, amino compounds 8a-e and 9a-c were prepared and screened against P. falciparum in vitro. Amino steroid 8d was the most active of the series with a minimum inhibiting concentration (MIC) of 0.5 μg/mL.