Sozial- und Präventivmedizin

, Volume 51, Issue 2, pp 99–109

Reference values for serum lipids and lipoproteins in Spanish adolescents: the AVENA study

  • Jonatan R Ruiz
  • Francisco B Ortega
  • Luis A Moreno
  • Julia Wärnberg
  • Marcela Gonzalez-Gross
  • Maria D Cano
  • Angel Gutierrez
  • Manuel J Castillo
  • the AVENA Study Group
Section: International Comparison of Health Determinants

DOI: 10.1007/s00038-005-0021-9

Cite this article as:
Ruiz, J.R., Ortega, F.B., Moreno, L.A. et al. Soz.-Präventivmed. (2006) 51: 99. doi:10.1007/s00038-005-0021-9
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Summary.

Objectives

To provide current reference values for serum lipid and lipoprotein levels in Spanish adolescents according to age and sex.

Methods

A cross sectional study conducted in five representative Spanish cities (Granada, Madrid, Murcia, Santander and Zaragoza) including a representative sample of 581 adolescents (299 male and 282 female), aged 13 to 18.5 years. Age- and sex-specific means, standard deviations and percentiles were determined for: Total (TC), high density lipoprotein (HDLc) and low density lipoprotein (LDLc) cholesterol, triglycerides, apolipoprotein A-1 and B-100, and lipoprotein(a).

Results

The 90th percentile for TC was 4.95 mmol/L for males and 5.19 mmol/L for females. HDLc levels were significantly higher in females of all age groups. LDLc levels ranged from 2.32 to 2.54 mmol/L in males and from 2.38 to 2.62 mmol/L in females, peaking at 13 years of age in both sexes. Triglyceride levels tended to increase gradually and to peak at 17 years of age for both sexes. Apolipoprotein A-1 and B-100 levels paralleled those of HDLc and LDLc values, respectively. The geometric mean for lipoprotein(a) levels ranged from 0.44 to 0.57 μmol/L in males and from 0.50 to 0.67 μmol/L in females.

Conclusions

The present study provides reference data on the distribution of lipid and lipoprotein levels of Spanish adolescents.

Keywords.

Adolescents Lipids Lipoproteins Cardiovascular disease Percentiles 

Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  • Jonatan R Ruiz
    • 1
    • 7
  • Francisco B Ortega
    • 1
  • Luis A Moreno
    • 2
  • Julia Wärnberg
    • 3
    • 4
  • Marcela Gonzalez-Gross
    • 1
    • 5
  • Maria D Cano
    • 6
  • Angel Gutierrez
    • 1
  • Manuel J Castillo
    • 1
  • the AVENA Study Group
  1. 1.Departamento de Fisiología, Facultad de MedicinaUniversidad de GranadaGranadaSpain
  2. 2.EU Ciencias de la SaludUniversidad de ZaragozaZaragozaSpain
  3. 3.Grupo Inmunonutrición, Departamento de Nutrición y MetabolismoConsejo Superior de Investigaciones CientíficasMadridSpain
  4. 4.Unit for Preventive Nutrition, Department of Biosciences at NovumKarolinska InstitutetHuddingeSweden
  5. 5.Facultad de CC. de la Actividad Física y el DeporteUniversidad Politécnica de MadridMadridSpain
  6. 6.Sección de Lípidos del Hospital Clínico UniversitarioGranadaSpain
  7. 7.Department of Medical Physiology, School of MedicineUniversity of GranadaGranadaSpain

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