The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells
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The effect of interleukin (IL)-17 on the activation of inducible nitric oxide (NO) synthase (iNOS) and subsequent production of NO was investigated. IL-17 induced NO production in both mouse and rat endothelial cells in a dose- and time-dependent manner. This was paralleled by the induction of mRNA for iNOS, which was markedly down-regulated by specific antagonists of protein tyrosine kinase, p38 MAP kinase or iNOS transcription factor NF-κB. The expression of iNOS transcription factor IRF-1 was also induced by IL-17 and blocked by all three inhibitors, suggesting that the induction of iNOS by IL-17 might be partly exerted through IRF-1 activation. Neutralization with the specific antibody showed that endogenous IL-17 is involved in T cell-mediated NO production in endothelial cells and NO-dependent suppression of T cell growth. These data indicate that IL-17-triggered iNOS activation in endothelial cells might participate in regulation of the T cell-dependent inflammatory response.
- The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells
Cellular and Molecular Life Sciences CMLS
Volume 60, Issue 3 , pp 518-525
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- Birkhäuser Verlag
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- Key words. Endothelial cell; interleukin-17; nitric oxide; iNOS; IRF-1.
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- Author Affiliations
- A1. Institute for Biological Research 'Sinisa Stankovic', 29 Novembra 142, 11060 Belgrade (Yugoslavia), Fax: +381 11 657 258, e-mail: firstname.lastname@example.org, YU
- A2. Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Belgrade (Yugoslavia), YU