Cellular and Molecular Life Sciences CMLS

, Volume 57, Issue 1, pp 16–24

Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrix

Authors

  • J. Ivaska
    • MediCity Research Laboratory and the Department of Medical Biochemistry, University of Turku, FIN-20520 Turku (Finland), Fax +358 2333 7000, e-mail: jyrki.heino@utu.fi
  • J. Heino*
    • MediCity Research Laboratory and the Department of Medical Biochemistry, University of Turku, FIN-20520 Turku (Finland), Fax +358 2333 7000, e-mail: jyrki.heino@utu.fi

DOI: 10.1007/s000180050496

Cite this article as:
Ivaska, J. & Heino*, J. CMLS, Cell. Mol. Life Sci. (2000) 57: 16. doi:10.1007/s000180050496

Abstract.

The integrins are a large family of heterodimeric cell adhesion receptors mediating cell-matrix and cell-cell adhesion. They seem to play a central role in cell migration and invasion and are therefore essential in processes such as healing of tissue injuries and the progression of human cancer. Integrins function in cell invasion by mediating cell movement on matrix molecules and also by regulating the expression of matrix-degrading enzymes, namely the matrix metalloproteinases. Here we review recent findings on the mechanisms by which integrins regulate matrix degradation. A novel, multistep model of integrin-guided collagen degradation is proposed.

Key words. Integrins; cell adhesion; signaling; matrix metalloproteinases; cell invasion; collagen.

Copyright information

© Birkhäuser Verlag Basel, 2000