The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems
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The hypothalamus regulates diverse physiological functions, including the control of energy metabolism, circadian rhythms, stress and anxiety, sexual and reproductive behaviors. An overview of the most prevalent hypothalamus-enriched mRNAs revealed that this area of the brain specializes in producing intercellular signaling molecules. Two new secreted peptides derived from a single neuropeptide precursor, named hypocretins and orexins by two different groups, are synthesized in a small set of neurons in the perifornical area of the hypothalamus. Intracerebroventricular injection of the hypocretins/orexins increases food consumption in rats. Here we review recent progress in identifying the role of the hypocretins/orexins in the control of energy balance and in other physiological systems.
- The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems
Cellular and Molecular Life Sciences CMLS
Volume 56, Issue 5-6 , pp 473-480
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- Birkhäuser Verlag
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- Key words. Leptin; neuropeptide Y; perifornical area; lateral hypothalamus; food consumption; obesity.
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