Cellular and Molecular Life Sciences CMLS

, Volume 56, Issue 5, pp 427–441

Integrin antagonists

  • G. P. Curley
  • H. Blum
  • M. J. Humphries

DOI: 10.1007/s000180050443

Cite this article as:
Curley, G., Blum, H. & Humphries, M. CMLS, Cell. Mol. Life Sci. (1999) 56: 427. doi:10.1007/s000180050443

Abstract.

Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response. Aberrant cell adhesion has been implicated in the pathogenesis of several diseases, including a number of inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and asthma, as well as cancer and coronary heart disease. As such integrins are seen as excellent targets for the development of therapeutic agents. This report begins with an examination of the structure of integrin molecules and their ligands and then goes on to review the current state of development of antiintegrin antagonists.

Key words. Integrins; cell adhesion; antagonists; inflammation; cancer; arthritis; therapeutics.

Copyright information

© Birkhäuser Verlag Basel, 1999

Authors and Affiliations

  • G. P. Curley
    • 1
  • H. Blum
    • 2
  • M. J. Humphries
    • 1
  1. 1.School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT (UK)GB
  2. 2.Hoechst Marion Roussel, DG Rheumatic/Autoimmune Diseases, D-65926 Frankfurt (Germany), e-mail: Martin.Humphries@man.ac.ukDE