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Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response. Aberrant cell adhesion has been implicated in the pathogenesis of several diseases, including a number of inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and asthma, as well as cancer and coronary heart disease. As such integrins are seen as excellent targets for the development of therapeutic agents. This report begins with an examination of the structure of integrin molecules and their ligands and then goes on to review the current state of development of antiintegrin antagonists.
- Integrin antagonists
Cellular and Molecular Life Sciences CMLS
Volume 56, Issue 5-6 , pp 427-441
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- Birkhäuser Verlag
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- Key words. Integrins; cell adhesion; antagonists; inflammation; cancer; arthritis; therapeutics.
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- Author Affiliations
- A1. School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT (UK), GB
- A2. Hoechst Marion Roussel, DG Rheumatic/Autoimmune Diseases, D-65926 Frankfurt (Germany), e-mail: Martin.Humphries@man.ac.uk, DE