Cellular and Molecular Life Sciences CMLS

, Volume 55, Issue 1, pp 64–75

Clinical implications of p53 mutations

  • R. R. Wallace-Brodeur
  • S. W. Lowe

DOI: 10.1007/s000180050270

Cite this article as:
Wallace-Brodeur, R. & Lowe, S. CMLS, Cell. Mol. Life Sci. (1999) 55: 64. doi:10.1007/s000180050270


The ultimate goal of basic cancer research is to provide a theoretical foundation for rational approaches to improve cancer therapy. Our extensive insight into the biology of the p53 tumour suppressor and the clinical behaviour of tumours harbouring p53 mutations indicates that information concerning p53 will be useful in diagnosis and prognosis, and may ultimately produce new therapeutic strategies. At the same time, efforts to understand the clinical implications of p53 mutations have revealed conceptual and technical limitations in translating basic biology to the clinic. The lessons learned from p53 may lay the groundwork for future efforts to synthesize cancer gene function, cancer genetics and cancer therapy.

Key words. Apoptosis; chemotherapy; prognosis; tumor suppressor; cancer genetics; clinical outcome.

Copyright information

© Birkhäuser-Verlag, Basel 1999

Authors and Affiliations

  • R. R. Wallace-Brodeur
    • 1
  • S. W. Lowe
    • 1
  1. 1.Cold Spring Harbor Laboratory, 1 Bungtown Rd., P.O. Box 100, Cold Spring Harbor (New York 11724, USA), Fax +1 516 367 8454, e-mail: lowe@cshl.orgUS