, Volume 54, Issue 9, pp 928-934
Date: 06 Feb 2014

The role of APOE polymorphisms in late-onset dementias

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Epidemiologic and laboratory results consistently implicate the APOE gene in the pathogenesis of late-onset Alzheimer's disease (AD) the ε4 allele increases risk in a dose-dependent fashion, while ε2 confers protection. Individuals are susceptible for AD in varying degrees depending on which combination of APOE alleles has been inherited, APOE promoter polymorphism and other factors. Deposition of both senile plaques and neurofibrillary tangles, the pathologic hall marks of AD, are enhanced by ε4 from the earliest lesions onward – diffuse plaques consisting of Aβ 1 – 42 and neurofibrillary tangles in the entorhinal cortex. Transgenic APOE mice carrying an APP mutation and 0, 1 or 2 copies of APOE showed dose-related increases in plaque deposition in the hippocampus and cortex, a clear indication that APOEp promotes Aβ deposition. The presence of each additional APOE ε4 allele leads to an earlier onset of the histopathological process of about 1 decade, on average. The association of both types of AD-related changes with the occurrence of ε4 suggests that the APOE polymorphism causally contributes to the pathogenesis of AD.