Cellular and Molecular Life Sciences CMLS

, Volume 54, Issue 9, pp 925–927

Chromosome 3-linked frontotemporal dementia

  • J. Brown

DOI: 10.1007/s000180050222

Cite this article as:
Brown, J. CMLS, Cell. Mol. Life Sci. (1998) 54: 925. doi:10.1007/s000180050222


Frontotemporal dementia accounts for a significant minority of all cases of presenile dementia. Many pedigrees have been described in which frontotemporal dementia is inherited as an autosomal dominant trait. Frontotemporal dementia is genetically heterogeneous with loci identified on chromosome 17 and chromosome 3. Clinical, pathological and genetic findings are described in a large Danish family in which the disease gene lies in the pericentromeric region of chromosome 3.

Key words. Frontotemporal dementia; Pick's disease; chromosome 3.

Copyright information

© Birkhäuser-Verlag, Basel 1998

Authors and Affiliations

  • J. Brown
    • 1
  1. 1.Department of Neurology, P.O. Box 165, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ (UK)UK