What have snakes taught us about integrins?
- T.-F. Huang
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Snake venoms contain unique components that affect cell-matrix interactions. Disintegrins represent a class of low molecular weight, Arg-Gly-Asp (RGD)-containing, cysteine-rich peptides purified from the venom of various snakes among the Viperidae and Crotalidae. They bind with various degrees of specificity to integrins α IIb β 3 , α 5 β 1 and α V β 3 expressed on cells. Snake venom metalloproteases (high molecular mass haemorrhagins) also contain disintegrin-like domains, in addition to zinc-chelating sequences. Membrane-anchored ADAMs (A Disintegrin And Metalloprotease domain), multidomain molecules consisting of metalloprotease, disintegrin-like, cysteine-rich, and epidermal growth factor domains, a transmembrane domain and a cytoplasmic tail, are a new family of proteins. In the light of the large number and wide distribution of ADAMs, they may participate in cell-cell fusion events, including sperm-egg binding and fusion, myoblast fusion and other cell-cell and cell-matrix interactions. The structure-function relationship of these molecules is discussed.
- What have snakes taught us about integrins?
Cellular and Molecular Life Sciences CMLS
Volume 54, Issue 6 , pp 527-540
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- Birkhäuser Verlag
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- Key words. Snake venom disintegrin; metalloprotease; ADAMs; integrin αIIb β3 , α2 β1 , αV β 3 ; platelet aggregation; haemorrhage; cell-matrix interaction; cell fusion.
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- T.-F. Huang (A1)
- Author Affiliations
- A1. Pharmacological Institute, College of Medicine, National Taiwan University, 1, Jen-Ai Rd., 1st Sec, Taipei (Taiwan), Fax +886 02 341 7930, e-mail: firstname.lastname@example.org, TW