Three-dimensional structure of annexins
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Annexins constitute a family of structurally related calcium- and phospholipid-binding proteins whose molecular structure has been investigated in detail in the crystalline and membrane-bound form. Their polypeptide chain is folded into four or eight α-helical domains of similar structure with a central hydrophilic pore. Bound to phospholipid membranes, the four-domain arrangement of the annexin molecule is conserved. A peripheral binding mode has been well documented by electron microscopy and a variety of other techniques.
- Three-dimensional structure of annexins
Cellular and Molecular Life Sciences CMLS
Volume 53, Issue 6 , pp 516-521
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- Birkhäuser Verlag
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- Key words. Annexin; crystal structure; electron microscopy; interfacial membrane proteins; ion channel.
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