Abstract
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess immunomodulatory functions that have been investigated as potential treatments in various immune disorders. MSCs can robustly interact with cells of the innate and adaptive immune systems, either through direct cell–cell contact or through their secretome. In this review, we discuss current findings regarding the interplay between MSCs and different immune cell subsets. We also draw attention to the mechanisms involved.
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Abbreviations
- MSCs:
-
Mesenchymal stem cells;
- Sca-1:
-
Stem cell antigen-1
- ESCs:
-
Embryonic stem cells
- iPSCs:
-
Induced pluripotent stem cells
- Th:
-
T-helper
- TGF-β:
-
Transforming growth factor beta
- HGF:
-
Hepatocyte growth factor
- IFN:
-
Interferon
- Treg:
-
Regulatory T cell
- NK:
-
Natural killer
- DC:
-
Dendritic cell
- EAE:
-
Experimental autoimmune encephalomyelitis
- SLE:
-
Systemic lupus erythematosus
- GVHD:
-
Graft-versus-host disease
- TNF:
-
Tumor necrosis factor
- IL:
-
Interleukin
- iNOS:
-
Nitric oxide synthase
- COX:
-
Cyclooxygenase
- NO:
-
Nitric oxide
- PGE2:
-
Prostaglandin E2
- CXCR3:
-
CXC chemokine receptor3
- CCR5:
-
C-C chemokine receptor type 5
- ICAM-1:
-
Intercellular adhesion molecule 1
- VCAM-1:
-
Vascular cell adhesion molecule 1
- IDO:
-
Indoleamine 2,3-dioxygenase
- HLA-G5:
-
Human leukocyte antigen class I molecule G5
- EV:
-
Extracellular vesicle
- TSG6:
-
Tumor necrosis factor-induced protein 6
- Breg:
-
Regulatory B cell
- STAT3:
-
Signal transducer and activator of transcription 3
- Blimp1:
-
B lymphocyte-induced maturation protein 1
- IL-1Ra:
-
IL-1 receptor antagonist
- APC:
-
Antigen-presenting cell
- MIF:
-
Macrophage migration inhibitory factor.
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Acknowledgements
This study was done with the support of Grants from the China National Basic Research Program (JFYS 2016YFA0100203), the National Natural Science Foundation of China (31272518, 31572399), and the Program of the Shaanxi Province (2015NY157).
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Li, N., Hua, J. Interactions between mesenchymal stem cells and the immune system. Cell. Mol. Life Sci. 74, 2345–2360 (2017). https://doi.org/10.1007/s00018-017-2473-5
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DOI: https://doi.org/10.1007/s00018-017-2473-5