Cellular and Molecular Life Sciences

, Volume 74, Issue 5, pp 849–867

Determination of the connectivity of newborn neurons in mammalian olfactory circuits

Review

DOI: 10.1007/s00018-016-2367-y

Cite this article as:
Ravi, N., Sanchez-Guardado, L., Lois, C. et al. Cell. Mol. Life Sci. (2017) 74: 849. doi:10.1007/s00018-016-2367-y

Abstract

The mammalian olfactory bulb is a forebrain structure just one synapse downstream from the olfactory sensory neurons and performs the complex computations of sensory inputs. The formation of this sensory circuit is shaped through activity-dependent and cell-intrinsic mechanisms. Recent studies have revealed that cell-type specific connectivity and the organization of synapses in dendritic compartments are determined through cell-intrinsic programs already preset in progenitor cells. These progenitor programs give rise to subpopulations within a neuron type that have distinct synaptic organizations. The intrinsically determined formation of distinct synaptic organizations requires factors from contacting cells that match the cell-intrinsic programs. While certain genes control wiring within the newly generated neurons, other regulatory genes provide intercellular signals and are only expressed in neurons that will form contacts with the newly generated cells. Here, the olfactory system has provided a useful model circuit to reveal the factors regulating assembly of the highly structured connectivity in mammals.

Keywords

DevelopmentSynaptogenesisCell fateTranscription factorMouse

Abbreviations

AON

Anterior olfactory cortex

EPL

External plexiform layer

ETC

External tufted cells

GC

Granule cell

GCL

Granule cell layer

MC

Mitral cell

MCL

Mitral cell layer

MTC

Middle tufted cells

OSN

Olfactory sensory neurons

Copyright information

© Springer International Publishing 2016

Authors and Affiliations

  1. 1.Central Institute of Mental Health, Medical Faculty MannheimHeidelberg UniversityMannheimGermany
  2. 2.Division of Biology and Biological EngineeringCalifornia Institute of TechnologyPasadenaUSA