Cellular and Molecular Life Sciences

, Volume 73, Issue 9, pp 1787–1802

Mechanism of ciliary disassembly

Review

DOI: 10.1007/s00018-016-2148-7

Cite this article as:
Liang, Y., Meng, D., Zhu, B. et al. Cell. Mol. Life Sci. (2016) 73: 1787. doi:10.1007/s00018-016-2148-7
  • 2k Downloads

Abstract

As motile organelles and sensors, cilia play pivotal roles in cell physiology, development and organ homeostasis. Ciliary defects are associated with a class of cilia-related diseases or developmental disorders, termed ciliopathies. Even though the presence of cilia is required for diverse functions, cilia can be removed through ciliary shortening or resorption that necessitates disassembly of the cilium, which occurs normally during cell cycle progression, cell differentiation and in response to cellular stress. The functional significance of ciliary resorption is highlighted in controlling the G1-S transition during cell cycle progression. Internal or external cues that trigger ciliary resorption initiate signaling cascades that regulate several downstream events including depolymerization of axonemal microtubules, dynamic changes in actin and the ciliary membrane, regulation of intraflagellar transport and posttranslational modifications of ciliary proteins. To ensure ciliary resorption, both the active disassembly of the cilium and the simultaneous inhibition of ciliary assembly must be coordinately regulated.

Keywords

Chlamydomonas IFT Aurora-A Plk1 Protein phosphorylation Wnt signaling Ciliary length control 

Abbreviations

IFT

Intraflagellar transport

MT

Microtubule

NaPPi

Sodium pyrophosphate

Plk1

Polo-like kinase 1

Dvl2

Dishevelled 2

Copyright information

© Springer International Publishing 2016

Authors and Affiliations

  1. 1.MOE Key Laboratory of Protein Sciences, School of Life SciencesTsinghua UniversityBeijingChina
  2. 2.Laboratory for Marine Biology and BiotechnologyQingdao National Laboratory for Marine Science and TechnologyQingdaoChina

Personalised recommendations