Cellular and Molecular Life Sciences

, Volume 72, Issue 10, pp 1863–1879

Cellular factors modulating the mechanism of tau protein aggregation

  • Sarah N. Fontaine
  • Jonathan J. Sabbagh
  • Jeremy Baker
  • Carlos R. Martinez-Licha
  • April Darling
  • Chad A. Dickey
Review

DOI: 10.1007/s00018-015-1839-9

Cite this article as:
Fontaine, S.N., Sabbagh, J.J., Baker, J. et al. Cell. Mol. Life Sci. (2015) 72: 1863. doi:10.1007/s00018-015-1839-9

Abstract

Pathological accumulation of the microtubule-associated protein tau, in the form of neurofibrillary tangles, is a major hallmark of Alzheimer’s disease, the most prevalent neurodegenerative condition worldwide. In addition to Alzheimer’s disease, a number of neurodegenerative diseases, called tauopathies, are characterized by the accumulation of aggregated tau in a variety of brain regions. While tau normally plays an important role in stabilizing the microtubule network of the cytoskeleton, its dissociation from microtubules and eventual aggregation into pathological deposits is an area of intense focus for therapeutic development. Here we discuss the known cellular factors that affect tau aggregation, from post-translational modifications to molecular chaperones.

Keywords

Tau Alzheimer’s disease Tauopathy Aggregation 

Copyright information

© Springer Basel 2015

Authors and Affiliations

  • Sarah N. Fontaine
    • 1
  • Jonathan J. Sabbagh
    • 1
  • Jeremy Baker
    • 1
  • Carlos R. Martinez-Licha
    • 1
  • April Darling
    • 1
  • Chad A. Dickey
    • 1
  1. 1.Department of Molecular Medicine, College of Medicine, Byrd Alzheimer’s InstituteUniversity of South FloridaTampaUSA